Melanoma is a made up of melanocytic tumours, and although these only represents 4% of all malignant skin tumours, they have the worst prognosis. In recent years, there have been advances in metastatic melanoma treatment, from a situation where there was no effective treatment to now having two therapeutic innovations: targeted therapies, and immunotherapy. The objective of this paper is bibliographic research by means of different databases and scientific journals to determine whether or not these new therapies represent an advantage in terms of efficacy and safety. The results of several studies have demonstrated the superiority of these treatments versus conventional chemotherapy; indeed, it has been relegated to the third or fourth line of treatment. In conclusion, the new therapies are more effective and safer than conventional chemotherapy, particularly the combination therapies.