Metabolic syndrome is a pathology that has exponentially increased its worldwide prevalence in the last few decades. However, its treatment is still not optimal, hence there is a big necessity to find better therapies. Soluble Epoxide Hydrolase, an enzyme involved in the arachidonic acid cascade, has recently arisen as one of the potential targets to treat metabolic syndrome. It is believed that the selective inhibition of this enzyme could lead to positive effects in several disorders that conform the disease. Many compounds have been synthetized and tested, several of them presenting a high inhibitory potency. Nevertheless, none has yet reached the market due to their poor pharmacokinetic profiles. Over the years, many strategies have been followed to overcome this issue. In this dissertation, the enzyme structure and function, the physiologic role of its metabolic substrates, and the design of the different classes of inhibitors are reviewed.