Psoriasis is an autoimmune inflammatory skin disease characterized by the hyperproliferation of keratinocytes and anomalous keratinization, which generates white plaques. Currently there is no cure for psoriasis, however the available treatments are based on topical and systemic therapies, which have benefits but can cause side effects that limit their usage. Conventional topical treatments have several limitations that emphasize the lack of a cure and an effective treatment. For this reason, pharmacotherapy for psoriasis could benefit from advances in nanomedicine: the design of new nanosystems overcomes the limitations of conventional topical therapy. Thus, the application of nanotechnology could imply significant improvements to the topical treatment of psoriasis.