Educació en competències: TFG - Farmàcia
Pedreira Rincón, Júlial; Pérez Ràfols, Anna; Boix Montañés, Antonio
Abstract
This study was carried out at the University of Barcelona’s biopharmaceutics and pharmacokinetics laboratory. Several in vitro dissolution tests of nicotine transdermal patches (Nicotinell®) were performed using a pharmacopoeial Paddle-over-disk dissolution apparatus to study the effect that extreme pH conditions and different agitation rates could have over drug release. Various dissolution models were then matched to the experimental data using the DDsolver add-in program for Microsoft Excel, in order to find the most suitable descriptive equation. This was provided by the Peppas-Sahlins model, with m = 0.5, indicating that the release profile followed a dual mechanism of both erosion and diffusion to release the drug. In order to confirm this model selection several amodelistic parameters, such as the f2 similarity index were also calculated. The results show how the dissolution rate improves as a function of pH and, to a lesser extent, with an increase in agitation rate.
Keywords: nicotine, release conditions, transdermal route,
Reception date: 28/10/2019
Acceptance date: 15/11/2019