Current studies suggest that changes in epigenetic modifications are associated with aging and neurodegeneration. Chromatin alterations can contribute to the development of neurodegenerative diseases, as has been reported in cases of Alzheimer’s disease. As our understanding of this pathology has advanced, epigenetic regulation by methyltransferase G9a has been suggested as an important mechanism involved in learning and memory formation. In the cell, G9a forms a complex with G9a-like protein (GLP), which is responsible for depositing methyl groups to the lysine-9 position of histone H3 (H3K9) in euchromatin. This H3K9 methylation is an indicator of silence transcription, which has been associated with autophagy and synaptic plasticity deficiencies.