Educació en competències: TFG-Farmàcia
Sierra Urueña, Yanik
Abstract
Streptococcus pneumoniae is a significant cause of infectious diseases such as community-acquired pneumonia or meningitis. After diagnosis by MALDI-TOF identification and antibiotic susceptibility tests, monitoring of the disease is established by serotyping tests, genotyping tests, and characterization of resistance mechanisms, especially transferable by transposon Tn916 in ermB and mef genes associated with macrolide resistance, and the tetM gene associated with tetracycline resistance. This whole process is needed to confirm the existence of different multidrug resistant clones that emerged and spread throughout the world decades ago, generated by selective adaptation while naturally residing within the human upper respiratory pathways. Nowadays, the prevention of Pneumococcal disease is based on vaccination the capsular polysaccharide is the major determinant of virulence of Streptococcus pneumoniae and it is considered the basis of current vaccine development.
Keywords: Streptococcus pneumoniae, resistance, serotyping, genotyping, vaccine.
Reception date: 23/05/2017
Acceptance date: 16/06/2017